![]() Every year, a small number of people (approximately 10-15 per year) in the southwestern U.S. Today, plague exists as a disease of wild rodents in most of the arid regions of the world, including the western U. ![]() ![]() If untreated, fatality rates of septicemic and pneumonic plague are as high as 50-90%, and they approach 15% even when treated promptly with antibiotics. In addition to damaging organs and causing internal hemorrhage, septicemic plague can develop rapidly into a highly infectious disease condition known as "pneumonic plague." In pneumonic plague, bacteria infect a patient's lungs and may be spread via coughing. This form of plague is known as "bubonic plague," which, if untreated, can develop into a form of plague known as "septicemic plague." In septicemic plague, bacteria invade the blood and infect major body organs. The initial infection following feeding by an infected flea is marked by painful, swollen lymph nodes, initially in the groin region. Historically, plague outbreaks have started slowly with transmission of the disease agent, a bacterium, via the bite of infected rodent fleas, primarily the Oriental rat flea, but then developed into rapidly growing epidemics involving human-to-human transmission (see below). Plague has surfaced several times in major, world-wide epidemics, one of the most important of which was the so-called "black death" that devastated Europe in the 14th century, when an estimated 25,000,000 people died.
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